Gene Delivery to Joints by Intra-Articular Injection
نویسندگان
چکیده
منابع مشابه
Treatment of arthritis by intra-articular injection.
In a previous paper (1948) a clinic for the treatment of osteoarthritis was described and certain conclusions were drawn. The technique used was that described by Waugh (1939). The value of this method of intra-articular injection was considered proven but the value of acid solutions not proven. It was felt that the success was due to varying combinations of three factors. Firstly, the injectio...
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OBJECTIVE (1) To measure objectively the subjective improvement in joint stiffness following intra-articular injections of corticosteroids, and (2) to record changes in joint stiffness in the first 24 hours after injection to look for changes in the physical properties of the joint that would be consistent with a crystal synovitis. METHODS The study population consisted of 15 patients having ...
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Piroxicam (PRX), a potent nonsteroidal anti-inflammatory drug, is prescribed to relieve postoperative and/or chronic joint pain. However, its oral administration often results in serious gastrointestinal adverse effects including duodenal ulceration. Thus, a novel cationic nanoparticle (NP) was explored to minimize the systemic exposure and increase the retention time of PRX in the joint after ...
متن کاملThe effect of intra-articular stimulation by pulsed radiofrequency on chronic sacroiliac joint pain refractory to intra-articular corticosteroid injection
We investigated the degree of pain reduction following intra-articular (IA) pulsed radiofrequency (PRF) stimulation of the sacroiliac joint (SIJ) in patients with chronic SIJ pain that had not responded to IA corticosteroid injection. Twenty patients were recruited. Clinical outcomes after applying PRF stimulation of the SIJ were evaluated by a numeric rating scale (NRS) and a 7-point Likert sc...
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Efficacy Intra-articular corticosteroid injection is quick and simple to carry out and in RCTs it has a large effect size (ES) of 1.27 at 7 days postinjection for pain relief against placebo for knee OA [101]. It produces relatively rapid relief of severe pain within a few hours or days. Although this benefit is relatively short lasting, in RCTs (1–4 weeks), individual patients may derive benef...
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ژورنال
عنوان ژورنال: Human Gene Therapy
سال: 2018
ISSN: 1043-0342,1557-7422
DOI: 10.1089/hum.2017.181